Reactive Arthritis (Reiter Syndrome) is a topic extended in the 5-Minute Clinical Consult.

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Reiter syndrome is a seronegative, multisystem, inflammatory disorder classically involving joints, the eye, and the reduced genitourinary (GU) tract. The is a postinfectious autoimmune process. Axial joint (e.g., spine, sacroiliac joints) and dermatologic manifestations are typical (1),(2).


The classic triad includes arthritis, conjunctivitis/iritis, and either urethritis or cervicitis (“can’t see; can not pee; can’t bend my knee”).

The public health is similar to various other reactive arthritides, defined by sterile share inflammation connected with infections originating at nonarticular sites. A fourth attribute (dermatologic involvement) may include buccal ulceration, balanitis, or a psoriasiform skin eruption. (Having just two features does not dominance out the diagnosis.)Two creates of Reiter syndrome:Sexuallytransfer : Symptoms emerge 7 to 14 job after exposure to Chlamydia trachomatis and also other sexually acquired pathogens.Postenteric infection (including traveler’s diarrhea)In people with new or frequent sexual partners, the triggering infection is likely sexuallytransfer (rather 보다 enteric).In people with a background of recent enteric illness, the triggering event is more likely to it is in a bacterial enteric infection than sex-related transmission.System(s) affected: musculoskeletal, renal/urologic, dermatologic/exocrineSynonym(s): idiopathic blennorrheal arthritis; arthritis urethritica; urethro-oculo-synovial syndrome; Fiessinger-Leroy-Reiter disease; reactive arthritis

Pediatric ConsiderationsJuvenile rheumatoid arthritis (RA) has countless of the same clinical features as Reiter syndrome.

Pregnancy ConsiderationsNo distinct considerations; usual drug precautions


IncidencePredominant age: 20 to 40 yearsPredominant sex: masculine > female0.2–1% incidence after bacter dysentery outbreaksComplicates 1–2% that nongonococcal urethritis cases~3–5 instances per 100,000 individuals per year.


The pathophysiology of every the seronegative reactive arthritis syndromes and the immunologic duty of transmittable diseases as precipitants because that clinical illness are incompletely understood. Proinflammatory cytokines bring about synovitis. Toll-like receptor (TLR) have actually been implicated in the acknowledgment of gram-negative lipopolysaccharide as component of the disease cascade.Avoiding precipitant infections and also early management of multiorgan inflammation is important. Antibiotic treatment adhering to onset that syndrome walk not appear to advantage inflammatory joint, eye, or urinary tract symptoms.C. Trachomatis is the most usual sexually sent infection linked with Reiter syndrome.Dysentery-associated Reiter syndrome adheres to infection through Shigella, Salmonella, Yersinia, and Campylobacter spp. Enteric-associated Reiter syndrome is much more common in women, children, and the elderly than the postvenereal form.

GeneticsHLA-B27 organization antigen current in 60–80% the patients, arguing a hereditary predisposition


New or high-risk sexual contacts 1–4 weeks prior to the beginning of clinical presentation; the main infection might be subclinical and also undiagnosed.Food poisoning or bacterial dysentery


The immune-response features of this syndrome do avoidance of infectious precipitants the most vital general precaution (and perhaps the most difficult to achieve).Safe sex-related practices; ideal food and water hygiene


Enteric diseaseShigellosis; Salmonellosis; CampylobacteriosisEnteric infection through Yersinia spp.Urogenital infectionMycoplasma or Ureaplasma spp.HIV/AIDS

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Reiter syndrome is a seronegative, multisystem, inflammation disorder classically including joints, the eye, and also the reduced genitourinary (GU) tract. That is a postinfectious autoimmune process. Axial share (e.g., spine, sacroiliac joints) and also dermatologic manifestations are typical (1),(2).


The classic triad has arthritis, conjunctivitis/iritis, and also either urethritis or cervicitis (“can’t see; can’t pee; can’t bending my knee”).

The public health is comparable to various other reactive arthritides, defined by sterile joint inflammation linked with infections originating in ~ nonarticular sites. A fourth feature (dermatologic involvement) may include buccal ulceration, balanitis, or a psoriasiform skin eruption. (Having only two attributes does not dominance out the diagnosis.)Two develops of Reiter syndrome:Sexually transmitted: Symptoms arise 7 to 14 work after exposure to Chlamydia trachomatis and also other sexually got pathogens.Postenteric epidemic (including traveler’s diarrhea)In people with brand-new or constant sexual partners, the triggering epidemic is most likely sexually sent (rather than enteric).In people with a background of recent enteric illness, the triggering occasion is much more likely to it is in a bacterial enteric infection than sex-related transmission.System(s) affected: musculoskeletal, renal/urologic, dermatologic/exocrineSynonym(s): idiopathic blennorrheal arthritis; arthritis urethritica; urethro-oculo-synovial syndrome; Fiessinger-Leroy-Reiter disease; reactive arthritis

Pediatric ConsiderationsJuvenile rheumatoid arthritis (RA) has numerous of the exact same clinical attributes as Reiter syndrome.

Pregnancy ConsiderationsNo special considerations; usual drug precautions


IncidencePredominant age: 20 to 40 yearsPredominant sex: male > female0.2–1% incidence after bacterial dysentery outbreaksComplicates 1–2% of nongonococcal urethritis cases~3–5 instances per 100,000 people per year.


The pathophysiology of every the seronegative reactive arthritis syndromes and also the immunologic role of transmittable diseases as precipitants for clinical disease are incompletely understood. Proinflammatory cytokines result in synovitis. Toll-like receptor (TLR) have actually been implicated in the acknowledgment of gram-negative lipopolysaccharide as part of the an illness cascade.Avoiding precipitant infections and early administration of multiorgan inflammation is important. Antibiotic treatment following onset of syndrome does not show up to advantage inflammatory joint, eye, or urinary street symptoms.C. Trachomatis is the most common sexually sent infection linked with Reiter syndrome.Dysentery-associated Reiter syndrome follows infection v Shigella, Salmonella, Yersinia, and Campylobacter spp. Enteric-associated Reiter syndrome is much more common in women, children, and also the elderly than the postvenereal form.

GeneticsHLA-B27 organization antigen current in 60–80% the patients, saying a genetic predisposition


New or high-risk sexual contacts 1–4 weeks prior to the beginning of clinical presentation; the main infection might be subclinical and undiagnosed.Food poisoning or bacter dysentery


The immune-response qualities of this syndrome do avoidance of contagious precipitants the most important general precaution (and perhaps the most challenging to achieve).Safe sexual practices; proper food and also water hygiene


Enteric diseaseShigellosis; Salmonellosis; CampylobacteriosisEnteric infection v Yersinia spp.Urogenital infectionMycoplasma or Ureaplasma spp.HIV/AIDS

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Domino, candid J., et al., editors. "Reactive Arthritis (Reiter Syndrome)." 5-Minute Clinical Consult, 27th ed., Wolters Kluwer, 2020. 5minute, www.tacoemojishirt.com/5minute/view/5-Minute-Clinical-Consult/816555/all/Reactive_Arthritis__Reiter_Syndrome_.
Reactive Arthritis (Reiter Syndrome). In: Domino FJF, Baldor RAR, Golding JJ, et al, eds. 5-Minute Clinical Consult. Wolters Kluwer; 2020. Https://www.tacoemojishirt.com/5minute/view/5-Minute-Clinical-Consult/816555/all/Reactive_Arthritis__Reiter_Syndrome_. Accessed November 15, 2021.

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Reactive Arthritis (Reiter Syndrome). (2020). In Domino, F. J., Baldor, R. A., Golding, J., & Stephens, M. B. (Eds.), 5-Minute Clinical top (27th edition). Wolters Kluwer. Https://www.tacoemojishirt.com/5minute/view/5-Minute-Clinical-Consult/816555/all/Reactive_Arthritis__Reiter_Syndrome_
Reactive Arthritis (Reiter Syndrome) . In: Domino FJF, Baldor RAR, Golding JJ, Stephens MBM, editors. 5-Minute Clinical Consult. Wolters Kluwer; 2020. . Obtainable from: https://www.tacoemojishirt.com/5minute/view/5-Minute-Clinical-Consult/816555/all/Reactive_Arthritis__Reiter_Syndrome_.
TY - ELECT1 - Reactive Arthritis (Reiter Syndrome)ID - 816555ED - Domino,Frank J,ED - Baldor,Robert A,ED - Golding,Jeremy,ED - Stephens,Mark B,BT - 5-Minute Clinical Consult, UpdatingUR - https://www.tacoemojishirt.com/5minute/view/5-Minute-Clinical-Consult/816555/all/Reactive_Arthritis__Reiter_Syndrome_PB - Wolters KluwerET - 27DB - 5minuteDP - Unbound MedicineER -

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